00F-4336-E0). manifestation after PDIA1 Robo2 silencing was decreased in HCT116, consistent with PDIA1 support of epithelialCmesenchymal transition. Therefore, Ras overactivation switches the pattern of PDIA1-dependent Rac1/Nox1 regulation, so that Ras-induced PDIA1 bypass can directly activate Rac1. PDIA1 may be a crucial regulator of redox-dependent adaptive processes related to malignancy progression. Introduction Protein disulfide isomerase (PDI … Continue reading 00F-4336-E0)